| Registro completo |
| Provedor de dados: |
Anais da ABC (AABC)
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| País: |
Brazil
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| Título: |
6-Gingerol inhibits hair cycle via induction of MMP2 and MMP9 expression
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| Autores: |
HOU,CHUN
MIAO,YONG
JI,HANG
WANG,SUSHENG
LIANG,GANG
ZHANG,ZHIHUA
HONG,WEIJIN
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| Data: |
2017-12-01
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| Ano: |
2017
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| Palavras-chave: |
MMP2
MMP9
6-Gingerol
Hair growth
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| Resumo: |
ABSTRACT 6-Gingerol is the major active constituent of ginger. In the current study, we aimed to investigate the mechanisms underlying the effects of 6-Gingerol on hair growth. Mice were randomly divided into five groups; after hair depilation (day 0), mice were treated with saline, or different concentrations of 6-Gingerol for 11 days. The histomorphological characteristics of the growing hair follicles were examined after hematoxylin and eosin staining. The results indicated that 6-Gingerol significantly suppressed hair growth compared with that in the control group. And choose the concentration of 6-Gingerol at 1 mg/mL to treated with mice. Moreover, 6-Gingerol (1 mg/mL) significantly reduced hair re-growth ratio, hair follicle number, and hair follicle length, which were associated with increased expression of MMP2 and MMP9. Furthermore, the growth factors, such as EGF, KGF, VEGF, IGF-1 and TGF-β participate in the hair follicle cycle regulation and regulate hair growth. We then measured the concentrations of them using ELISA assays, and the results showed that 6-Gingerol decreased EGF, KGF, VEGF, and IGF-1 concentrations, and increased TGF-β concentration. Thus, this study showed that 6-Gingerol might act as a hair growth suppressive drug via induction of MMP2 and MMP9 expression, which could interfere with the hair cycle.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000602707
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| Editor: |
Academia Brasileira de Ciências
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| Relação: |
10.1590/0001-3765201720170354
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| Formato: |
text/html
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| Fonte: |
Anais da Academia Brasileira de Ciências v.89 n.4 2017
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| Direitos: |
info:eu-repo/semantics/openAccess
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